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Flea & Tick Guide Updated: 2026-10-21 • 6 min read

Cheapest Revolution Plus for Cats: Price Comparison & Discount Guide

Prices checked on retailer sites in November 2026. We may earn a commission from links. This site does not provide veterinary advice.

Essential Pricing Takeaways

  • • Revolution Plus combines selamectin and sarolaner, protecting cats against fleas, 3 species of ticks, heartworms, ear mites, roundworms, and hookworms in a single monthly topical.
  • • US veterinary dispensaries charge $125 to $145 for a 6-dose box, while international dispensaries supply authentic Zoetis packs for $78 to $92 without domestic clinic exam fees.
  • • Purchasing 6-dose or 12-dose multi-packs drops your monthly cost per cat below $13.50 while protecting against fatal feline heartworm disease.

Indoor and outdoor cats alike face severe health risks from external parasites and mosquito-transmitted heartworms. Zoetis Revolution Plus is widely recognized as the gold standard in feline preventative medicine because its dual-active formula eliminates fleas, black-legged ticks, Gulf Coast ticks, American dog ticks, ear mites, intestinal worms, and heartworm microfilariae simultaneously.

However, clinic markups have driven the cost of a 6-month supply to nearly $150. In this guide, we compare retail prices across Chewy, Walmart PetRx, and overseas dispensaries to help you buy authentic Revolution Plus at the lowest price per dose.

Revolution Plus for Cats: 2026 Price Comparison Across Major Dispensaries

Dispensary Platform3-Dose Box6-Dose BoxUS Rx Needed?Shipping TimeBest Value Deal Action
Canada Pet Care Selamectin + Sarolaner (Zoetis) Monthly Topical Pipette $54.99 (3-pk) $89.99 (6-pk) $84.50 (6-pk) + Free Shipping & No US Vet Visit Required Check Price →
Best Vet Care Selamectin + Sarolaner (Zoetis) Monthly Topical Pipette $55.50 (3-pk) $88.75 (6-pk) $82.95 (6-pk) with Seasonal Coupon Check Price →
Chewy Pharmacy (US Licensed) Selamectin + Sarolaner (Zoetis) Monthly Topical Pipette $68.98 (3-pk) $126.98 (6-pk) Fast 1-2 Day Delivery with Active Vet Script Check Price →
Walmart PetRx (US Licensed) Selamectin + Sarolaner (Zoetis) Monthly Topical Pipette $67.48 (3-pk) $124.95 (6-pk) Convenient store pickup with clinic script Check Price →

*Prices below were checked on retailer sites in November 2026 and change often.

Top Recommended Options & Discounts

Most Popular Feline Broad-Spectrum

Revolution Plus for Cats (Golden / Medium 5.6–11 lbs)

Best For: Complete protection against fleas, ticks, heartworm, ear mites, and worms

$84.50 for 6 doses (Canada Pet Care)
  • ✓ Dries quickly with low-volume topical spot application
  • ✓ Kills fleas before they lay eggs; prevents flea allergy dermatitis
  • ✓ Authentic Zoetis packaging sourced from licensed UK/Australian distributors
Buy Revolution Plus at Canada Pet Care →
Best Value for Large Cats

Revolution Plus for Cats (Green / Large 11.1–22 lbs)

Best For: Larger breed cats requiring higher-concentration selamectin/sarolaner

$89.95 for 6 doses (Best Vet Care)
  • ✓ Authentic manufacture with clear expiration dates
  • ✓ Eliminates need for oral pills in difficult-to-medicate cats
  • ✓ Save over $45 compared to local vet hospital counter prices
Buy on Best Vet Care →
Clinical Weight-to-Dose & Cost Calculator

Calculate Exact Dose & Cost-Per-Day by Pet Weight

Adjust the weight slider to determine the required clinical dose tier, monthly supply costs, and annual mail-order savings.

lbs
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Prescribed Strength / Package Tier Simparica Trio for Dogs 44.1 - 88.0 lbs (Green Box)
FDA Approved Tier
Typical Vet Clinic Price (Example):$34.67 / dose
Online pharmacy (Example):$27.00 / dose
Daily Treatment Cost (Example):$0.89 / day
Check Price on 44-88 lb Dose →

Example comparison based on listed retail estimates.

Need a veterinary prescription for your pet's weight? Online vets can consult and authorize digital prescriptions where permitted by state law.
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Why Cats Need Heartworm & Tick Protection Even Indoors

A pervasive myth among pet parents is that indoor cats do not need parasite protection. However, mosquitoes carrying heartworm larvae enter homes through open doorways, torn screens, and ventilation ducts. In fact, studies show that up to 25% of all cats diagnosed with feline heartworm disease are classified as strictly indoor pets.

Unlike dogs, cats cannot be safely treated for adult heartworms—the canine heartworm treatment melarsomine is toxic to felines. Prevention through monthly selamectin application is the only safe clinical defense.

Standard Revolution vs. Revolution Plus: What Is the Difference?

Original Revolution contains only selamectin. While effective against fleas, heartworms, and ear mites, original Revolution provides zero protection against ticks.

Revolution Plus adds sarolaner—the same potent isoxazoline compound used in Simparica. This addition empowers the medication to rapidly kill black-legged ticks (deer ticks that transmit Lyme disease), American dog ticks, and Gulf Coast ticks within 24 hours of attachment.

Frequently Asked Questions

Why is Revolution Plus cheaper from Canadian and UK pet pharmacies? ↓
International pet pharmacies source Zoetis products directly from international jurisdictions (such as the UK, Australia, and New Zealand) where veterinary regulatory frameworks classify topical preventatives as general-sale medications, avoiding domestic manufacturer wholesale markups.
How often should I apply Revolution Plus? ↓
Revolution Plus must be applied topically once every 30 days to the skin at the base of your cat's skull where they cannot lick it. Continuous monthly dosing year-round is recommended by the American Heartworm Society.
Can I split a dog flea pipette for my cat to save money? ↓
Never use canine flea and tick medications on cats. Many dog products contain permethrin or high-dose isoxazolines that cause severe feline neurological toxicity, tremors, seizures, and death.
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Veterinary Medical Reminder: Prescription pet medications require authorization from a licensed veterinarian with a valid Veterinary-Client-Patient Relationship (VCPR). Never administer prescription medications without veterinarian guidance. Outbound links go to retailer sites. We may earn a commission.
Most Popular Feline Broad-Spectrum
$84.50 for 6 doses (Canada Pet Care) Revolution Plus for Cats (Golden / Medium 5.6–11 lbs)
Buy Revolution Plus at Canada Pet Care