Flea & Tick Meds for Dogs: Price Comparison & Pharmacy Guide

ProHeart 12 (moxidectin extended-release injectable suspension) provides 365 full days of continuous heartworm prevention in a single veterinary technician injection.

A canine heartworm blood test (typically an in-house IDEXX SNAP 4Dx Plus test) averages $35 to $65 at private veterinary clinics, plus a mandatory $50 to $85 physical exam fee.

Trifexis (spinosad + milbemycin oxime) by Elanco is a monthly beef-flavored chewable that kills adult fleas, prevents heartworm disease, and treats roundworms, hookworms, and whipworms.

Interceptor Plus (milbemycin oxime + praziquantel) protects against 5 distinct worm species: heartworms, hookworms, roundworms, whipworms, and tapeworms (Taenia and Dipylidium).

FDA-approved generic equivalents Tri-Heart Plus (Merck) and Iverhart Max provide the exact same Ivermectin and Pyrantel pamoate concentrations as Heartgard Plus.

Credelio (Lotilaner) is an advanced monthly isoxazoline flea and tick chewable, killing fleas within 4 hours and ticks within 8 hours.

Bravecto (Fluralaner) provides 12 full weeks (3 months) of continuous flea and tick defense from a single chewable or topical dose.

NexGard Plus combines Afoxolaner, Moxidectin, and Pyrantel into a monthly beef-flavored soft chew protecting against fleas, ticks, heartworms, and intestinal worms.

Purchasing a 12-month box of Simparica Trio qualifies for 450 Zoetis Petcare Rewards points, redeemable for a Visa prepaid card.

Oral isoxazoline chewables (Simparica Trio, NexGard, Bravecto) provide 99%+ kill efficacy and cannot wash off during baths or swimming.

Fast-acting oral tablets like Capstar (nitenpyram) begin killing adult fleas within 30 minutes, but provide no residual protection beyond 24 hours per the product label.

NexGard (afoxolaner) is administered every 30 days, while Bravecto (fluralaner) protects for 12 weeks per oral chew.

Simparica Trio combines sarolaner, moxidectin, and pyrantel to prevent heartworm disease, kill adult fleas and ticks, and treat intestinal roundworms and hookworms.

Simparica Trio contains an FDA-regulated heartworm preventative (moxidectin), requiring veterinarian authorization under United States federal pharmacy law.

Revolution Plus combines selamectin and sarolaner, protecting cats against fleas, 3 species of ticks, heartworms, ear mites, roundworms, and hookworms in a single monthly topical.

The top direct single-chew alternative to Simparica Trio is NexGard Spectra (afoxolaner + milbemycin oxime), which provides identical all-in-one monthly protection.

Purchasing Simparica Trio at brick-and-mortar veterinary clinics costs between $175 and $195 for a 6-month supply ($29 to $32 per monthly chew).

In the United States, FDA regulations classify all heartworm preventatives as prescription-only to ensure dogs test negative for active heartworms before dosing.

Heartgard Plus costs $48 to $62 per 6-dose box at US veterinary hospitals and retail pet pharmacies ($8 to $10 per monthly chew).