Cheapest Place to Buy Simparica Trio: 6 & 12 Month Price Comparison (2026)
Essential Pricing Takeaways
- • Simparica Trio combines sarolaner, moxidectin, and pyrantel to prevent heartworm disease, kill adult fleas and ticks, and treat intestinal roundworms and hookworms.
- • Purchasing 6-month boxes from online pharmacies such as Walmart PetRx ($162) or Chewy ($168) for large dogs saves up to $46 compared to average clinic retail ($208).
- • Zoetis offers manufacturer rewards points for qualifying purchases through authorized veterinary clinics and pharmacies, redeemable for future care and reward cards.
- • Before starting Simparica Trio, the American Heartworm Society recommends testing dogs 7 months of age and older for heartworm infection.
- • Simparica Trio is labeled for dogs 8 weeks and older and at least 2.8 lb.
- • Prices below were checked on retailer sites in November 2026 and change often.
Simparica Trio is a monthly chewable manufactured by Zoetis. It combines an isoxazoline flea and tick preventive (sarolaner), a heartworm preventive (moxidectin), and an intestinal dewormer (pyrantel pamoate) into a single liver-flavored tablet.
Because Simparica Trio provides broad-spectrum parasite protection, many pet owners rely on it year-round. However, purchasing 12 monthly doses through veterinary hospital desks can exceed $380 to $420 per year for medium and large dogs.
Retail pricing varies across dispensing pharmacies, warehouse clubs, and online dispensaries. Combining multi-month cartons with pharmacy auto-ship promotions and manufacturer rewards programs helps lower annual expenses.
This guide compares listed prices across canine weight brackets and outlines legitimate prescription purchasing workflows.
Simparica Trio 6-Month Supply Price Comparison by Dog Weight
| Weight Bracket | Active Ingredients | Vet Clinic Estimate | Costco Pharmacy | Chewy Price | Walmart PetRx Price | Action |
|---|---|---|---|---|---|---|
| Small Dogs (5.6 - 11 lbs) | 6mg / 0.12mg / 25mg | $182.00 | $156.00 | $162.00 | $156.00 | Check Price → |
| Medium Dogs (11.1 - 22 lbs) | 12mg / 0.24mg / 50mg | $188.00 | $161.00 | $164.00 | $161.00 | Check Price → |
| Medium/Large (22.1 - 44 lbs) | 24mg / 0.48mg / 100mg | $196.00 | $164.00 | $167.00 | $164.00 | Check Price → |
| Large Dogs (44.1 - 88 lbs) | 48mg / 0.96mg / 200mg | $208.00 | $166.00 | $168.00 | $162.00 | Check Price → |
| Extra Large (88.1 - 132 lbs) | 72mg / 1.44mg / 300mg | $219.00 | $170.00 | $172.00 | $168.00 | Check Price → |
*Prices below were checked on retailer sites in November 2026 and change often.
Top Recommended Options & Discounts
Walmart PetRx (Simparica Trio 6-Month)
Best For: Pet owners looking for competitive everyday pricing on authentic US-labeled cartons with free 2-day home shipping
- ✓ Direct electronic prescription coordination with your veterinarian
- ✓ Free 2-day shipping on pet medication orders over $35
- ✓ licensed online dispensary
- ✓ US manufacturer packaging eligible for rewards submission
Chewy Pharmacy (Simparica Trio Autoship)
Best For: Pet parents wanting automatic 6-month refill schedules and 24/7 customer support
- ✓ 5% discount on recurring scheduled autoship refills
- ✓ Pharmacy contacts your veterinary hospital directly for authorization
- ✓ Live customer care assistance available 24/7
- ✓ Authentic manufacturer inventory
Calculate Exact Dose & Cost-Per-Day by Pet Weight
Adjust the weight slider to determine the required clinical dose tier, monthly supply costs, and annual mail-order savings.
Example comparison based on listed retail estimates.
Simparica Trio Active Ingredients & Label Information
Simparica Trio combines three active compounds according to the FDA NADA 141-521 Freedom of Information Summary:
1. Sarolaner: An isoxazoline that kills adult fleas and five tick species: the black-legged tick, American dog tick, brown dog tick, Lone Star tick, and Gulf Coast tick.
2. Moxidectin: A macrocyclic lactone that prevents heartworm disease (Dirofilaria immitis) by eliminating tissue-stage larvae acquired during the prior 30 days.
3. Pyrantel Pamoate: An anthelmintic that treats and controls adult roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).
Pre-Treatment Heartworm Testing
Per the American Heartworm Society Canine Guidelines (2024/2025), dogs 7 months of age and older must be tested for existing heartworm infection before starting preventative therapy. Giving moxidectin to a dog with active circulating microfilariae can cause mild to severe hypersensitivity reactions from sudden microfilarial death.
Zoetis Petcare Rewards Program Details
Zoetis offers a manufacturer loyalty rewards program for purchases of Simparica Trio. Pet owners who purchase through participating veterinary practices and authorized online dispensaries can submit receipts on the Zoetis Petcare Rewards Simparica Trio Offer Page to earn points.
Points can be redeemed toward future veterinary care or prepaid cards according to current program rules. Check Zoetis's website for current point values and eligible retailers before purchasing.
Price Verification and Comparison
Prices below were checked on retailer sites in November 2026 and change often.
A single 6-month carton for a large dog costs $162 at Walmart PetRx and $168 at Chewy, compared to clinic desk averages of $208. Pet owners looking for alternative options can also review oral flea pills for dogs to evaluate single-ingredient flea medications.
Clinical Sources & References
• FDA NADA 141-521: Simparica Trio Freedom of Information Summary.
• American Heartworm Society: Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm Infection (2024/2025).
• Companion Animal Parasite Council (CAPC): Ectoparasite and Endoparasite Guidelines.
• Zoetis Petcare Rewards: Simparica Trio Current Offer Terms.