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Flea & Tick Guide Updated: 2026-10-27 • 7 min read

NexGard Plus Cost & Rebates: Boehringer Ingelheim 3-in-1 Chews

Prices checked on retailer sites in November 2026. We may earn a commission from links. This site does not provide veterinary advice.

Essential Pricing Takeaways

  • • NexGard Plus combines Afoxolaner, Moxidectin, and Pyrantel into a monthly beef-flavored soft chew protecting against fleas, ticks, heartworms, and intestinal worms.
  • • Boehringer Ingelheim Pet Rewards offers up to $60 in rebate credits when buying 12 doses of NexGard Plus from licensed veterinary providers.
  • • Discount online dispensaries price NexGard Plus at $32–$36 per dose, saving over $100 annually compared to clinic counter rates.

For years, dog owners had to choose between giving separate heartworm chews and flea/tick chews every month. Boehringer Ingelheim answered market demand by launching NexGard Plus—a true 3-in-1 monthly soft chew that combines afoxolaner (flea/tick), moxidectin (heartworm), and pyrantel (roundworm/hookworm).

As the primary competitor to Simparica Trio, pet parents often wonder how NexGard Plus pricing compares and where to find the best manufacturer discounts. In this 2026 pricing guide, we compare retail and pharmacy costs, rebate programs, and key value comparisons.

2026 NexGard Plus vs. Simparica Trio Price & Feature Comparison

3-in-1 Chewable ProductActive MoleculesChewy Pharmacy (6 Doses)Walmart PetRx (6 Doses)Manufacturer RebateBest Deal Verdict Action
NexGard Plus (Boehringer Ingelheim) Afoxolaner + Moxidectin + Pyrantel Real-Beef Soft Chew $198.00 ($33.00/dose) $194.50 ($32.41/dose) Boehringer Pet Rewards rebate + AutoShip savings Check Price →
Simparica Trio (Zoetis) Sarolaner + Moxidectin + Pyrantel Liver-Flavored Chewable $196.00 ($32.66/dose) $192.00 ($32.00/dose) Zoetis Petcare Rewards ($15–$45 Visa cards) Check Price →
Unbundled Generic Protocol (Tri-Heart + Generic Topical) Ivermectin + Pyrantel + Fipronil Oral Tablet + Topical Spot-On $72.00 (6 Months) $68.00 (6 Months) Saves over $240/year vs 3-in-1 brand chewables Check Price →

*Prices below were checked on retailer sites in November 2026 and change often.

Top Recommended Options & Discounts

Premier 3-in-1 Protection

NexGard Plus Chewables for Dogs

Best For: Dogs that love soft beef treats needing comprehensive flea, tick, heartworm, and intestinal worm coverage

$194.50 - $198.00 per 6-dose box ($32.41 / dose) • Rx Prescription Required
  • ✓ Triple-action formula eliminates the need for separate flea pills and heartworm chews
  • ✓ Made with real beef soft dough that dogs eat readily without pill-wrapping struggles
  • ✓ Free 1-2 day express shipping directly to your doorstep with electronic vet approval
Shop NexGard Plus Deals →
Max Rebate Eligibility

Walmart PetRx NexGard Plus 12-Month Refills

Best For: Maximizing the Boehringer Ingelheim $60 annual pet rebate with auto-delivery

$380.00 per 12-dose annual box • Rx Prescription Required
  • ✓ Qualifies for the maximum tier Boehringer Ingelheim Pet Rewards rebate voucher
  • ✓ Automatic prescription refill reminders so your dog never misses a monthly dose
  • ✓ Backed by national warehouse fulfillment and authentic manufacturer supply
Order at Walmart PetRx →
Clinical Weight-to-Dose & Cost Calculator

Calculate Exact Dose & Cost-Per-Day by Pet Weight

Adjust the weight slider to determine the required clinical dose tier, monthly supply costs, and annual mail-order savings.

lbs
Toy (5 lbs)Small (20 lbs)Medium (45 lbs)Large (75 lbs)Giant (110+ lbs)
Prescribed Strength / Package Tier Simparica Trio for Dogs 44.1 - 88.0 lbs (Green Box)
FDA Approved Tier
Typical Vet Clinic Price (Example):$34.67 / dose
Online pharmacy (Example):$27.00 / dose
Daily Treatment Cost (Example):$0.89 / day
Check Price on 44-88 lb Dose →

Example comparison based on listed retail estimates.

Need a veterinary prescription for your pet's weight? Online vets can consult and authorize digital prescriptions where permitted by state law.
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NexGard Plus vs. Simparica Trio: Which Is Better Value?

NexGard Plus and Simparica Trio share almost identical clinical profiles: both utilize moxidectin for heartworm protection and pyrantel for intestinal parasites. The only molecular difference is the flea/tick isoxazoline: NexGard Plus uses afoxolaner, while Simparica Trio uses sarolaner.

In terms of pricing, both products cost within $2 to $4 of each other across licensed pharmacies. The deciding factor for pet parents usually comes down to taste preference: dogs that prefer real beef chewables favor NexGard Plus, while dogs that prefer liver chews favor Simparica Trio (see our cheapest Simparica Trio price comparison).

Claiming Boehringer Ingelheim Pet Rewards on NexGard Plus

Boehringer Ingelheim operates a rewards portal (BoehringerPetRewards.com) where dog owners can submit invoices for NexGard Plus, Heartgard Plus, and NexGard.

Submitting a receipt for a 6-dose box yields a $15 rebate, while a 12-dose box earns $60 in Visa prepaid card rewards, dropping the net per-dose price below $27 (check our best place to order pet meds online guide).

Frequently Asked Questions

Does NexGard Plus require a prescription? ↓
Yes, because NexGard Plus contains moxidectin for heartworm prevention, US federal law mandates a valid veterinary prescription with a current negative heartworm blood test.
Can NexGard Plus cause seizures in dogs? ↓
Like all drugs in the isoxazoline class (afoxolaner, sarolaner, fluralaner, lotilaner), NexGard Plus should be used with caution in dogs with a history of seizures or neurological disorders.
At what age can puppies start NexGard Plus? ↓
NexGard Plus is FDA-approved for puppies 8 weeks of age and older weighing at least 4 pounds.
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Veterinary Medical Reminder: Prescription pet medications require authorization from a licensed veterinarian with a valid Veterinary-Client-Patient Relationship (VCPR). Never administer prescription medications without veterinarian guidance. Outbound links go to retailer sites. We may earn a commission.
Premier 3-in-1 Protection
$194.50 - $198.00 per 6-dose box ($32.41 / dose) NexGard Plus Chewables for Dogs
Shop NexGard Plus Deals